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Alhamdulillahirrabil alamin.
Gratitude we bid to Allah because giving us
another opportunity to live on this earth to worship Him
This post is specifically for my KOS 1110 assignment
Have you ever heard about Protein Data Bank??
Well then in this entry , I am going to give you just a brief explanation..:)
Introduction
The Protein Data Bank (PDB) is a repository for the 3-D structural data of large biological molecules, such as proteins and nucleic acids. (See also crystallographic database). The data, typically obtained by X-ray crystallography or NMR spectroscopy and submitted by biologistsand biochemists from around the world, are freely accessible on the Internet via the websites of its member organisations (PDBe, PDBj, and RCSB). The PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB.
The PDB is a key resource in areas of structural biology, such as structural genomics. Most major scientific journals, and some funding agencies, such as the NIH in the USA, now require scientists to submit their structure data to the PDB. If the contents of the PDB are thought of as primary data, then there are hundreds of derived (i.e., secondary) databases that categorize the data differently.
HISTORY
The PDB was established in 1971 at Brookhaven National Laboratory under the leadership of Walter Hamilton and originally contained 7 structures. After Hamilton's untimely death, Tom Koetzle began to lead the PDB in 1973, and then Joel Sussman in 1994. In 1998, the Research Collaboratory for Structural Bioinformatics (RCSB) became responsible for the management of the PDB. In 2003, the wwPDB was formed to maintain a single PDB archive of macromolecular structural data that is freely and publicly available to the global community. It consists of organizations that act as deposition, data processing and distribution centers for PDB data.
X Ray Crystallography
X-ray crystallography is a method of determining the atomic and molecular structure of a crystal, in which the crystalline atoms cause a beam of X-rays to diffract into many specific directions. By measuring
the angles and intensities of these diffracted beams, a crystallographer can produce a three-dimensional picture of the density of electrons within the crystal.
Protein Structures
Following are the image of protein retrieved from protein data bank:-
| Description | Molecule | Thermosylin |
| Type | protein |
| Length | 316 |
| Weight | 35646.59 |
| Polymer | 1 |
Sources:-
1. http://www.rcsb.org/pdb/home/home.do
2. http://en.wikipedia.org/wiki/Protein_Data_Bank
